Role of Carcinoma Associated Fibroblasts in Anoikis Resistance in Oral Squamous Cell Carcinoma –need of the hour

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Submitted: December 17, 2016
Published: Jan 30, 2017
DOI: 10.29328/journal.hjpcr.1001001

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Anjali Ganjre
Department of Oral Pathology, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, India

Abstract

Anoikis resistance (AR) is a favorable attribute exhibited by cancer cells for metastasis. Carcinoma associated Fibroblasts (CAFs) plays a crucial role in AR in various cancers. It was proved in array of studies in different cancers that there was definite interrelationship between CAFs and AR. But its role in OSCC is ambiguous. It is the need of the time to reveal the correlation of CAF and oral squamous cell carcinoma (OSCC) in relation with anoikis. Molecular pathways which affects the AR via CAFs in various cancers has been highlighted in this communication. Divulging the importance of CAF in cancer will aid in designing customized novel chemoprevention therapy and thus will help in enhancing the prognosis of patient in OSCC.

Article Details

Ganjre, A. (2017). Role of Carcinoma Associated Fibroblasts in Anoikis Resistance in Oral Squamous Cell Carcinoma –need of the hour. Archives of Pathology and Clinical Research, 1(1), 001–004. https://doi.org/10.29328/journal.hjpcr.1001001
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Copyright (c) 2017 Ganjre A.

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