Figure 1

Immune-mediated neuropathy related to bortezomib in a patient with multiple myeloma

Susanne Koeppen*, Jörg Hense, Kay Wilhelm Nolte and Joachim Weis

Published: 03 January, 2022 | Volume 6 - Issue 1 | Pages: 001-004

apcr-aid1028-g001

Figure 1:

Histological analysis of the sural nerve biopsy. (A) Two adjacent nerve fascicles showing severe axonal loss which is unevenly distributed throughout the fascicles and from fascicle to fascicle. Note some mononuclear inflammatory cells around small epineurial vessels (arrows) without vessel wall destruction (resin embedded tissue, semithin section, toluidine blue). (B) Semithin transverse section of a nerve fascicle with only a few myelinated nerve fibers preserved (black arrows), several acutely degenerating nerve fibers as well as myelion debris (white arrows). No hypertrophic changes (onion bulb formation), demyelinated axons or regeneration groups are seen (toluidine blue stain). (C) Numerous macrophages invading the endoneurium of a nerve fascicle, being focally clustered, e. g. around endoneurial vessels (arrows) (Paraffin section, CD68-immunostaining). (D) Cytotoxic T-lymphocytes (arrows) in the endoneurial compartment of a nerve fascicle (same as in C), sometimes closely related to vessels (white arrows) (immunohistochemical staining for the CD8 T cell surface antigen). (E, F) Mainly diffuse staining of largely equal intensity within the same nerve fascicle after incubation with antisera to immunoglobulin light chains (immunohistochemical staining for kappa, E, and lambda, F). Scale bar: (A, C, D) 90 µm, (B, E, F) 45 µm.

Read Full Article HTML DOI: 10.29328/journal.apcr.1001028 Cite this Article Read Full Article PDF

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