Abstract

Case Report

Post-operative agranulocytosis caused by intravenous cefazolin: A case report with a discussion of the pathogenesis

Charles M Lombard*, Jiali Li and Bijayee Shrestha

Published: 18 February, 2022 | Volume 6 - Issue 1 | Pages: 009-012

A case of post-operative agranulocytosis which occurred in a 66-year-old woman following surgery for endometrial carcinoma is reported. The agranulocytosis had a rapid onset, being detected on the first post-operative day. The causative agent, cefazolin was given to the patient intraoperatively. The agranulocytosis persisted until the 22nd postoperative day. A bone marrow biopsy performed on post-operative day four showed a left-shifted myeloid maturation pattern but not a maturation arrest. The pathogenesis of drug-induced neutropenia/agranulocytosis is discussed. It is postulated that reversible binding of cefazolin to albumin accounts for the prolonged duration of agranulocytosis.

Read Full Article HTML DOI: 10.29328/journal.apcr.1001030 Cite this Article Read Full Article PDF

Keywords:

Agranulocytosis; Neutropenia; Postoperative; Cephalosporin; Cephazolin; Pathogenesis

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